VPS13B — Vacuolar protein sorting 13 homolog B
VPS13B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VPS13B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Autophagy & Trafficking Housekeeping | ABCD2, ASCC3, ATG7, ATP9B, BTBD9, IKBKE, ITFG1, KLF12 +11 more | |
| Lymphatic endothelial | Polarized Vesicle Trafficking migration & adhesion | ELMO1, EXOC4, EXOC6B, IMMP2L, L3MBTL4, LRBA, LRMDA, MYO9A +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANK3, ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA +13 more | |
| Neutrophils | ELMO-DOCK Chemotaxis Chemotaxis | BCAS3, CDK19, DOCK2, ELMO1, KMT2C, NCOA2, STAG1 |
About the gene
| Synonyms | BLTP5B, CHS1, COH1 |
|---|---|
| Chromosome | 8: 99013266-99877580 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3- phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes. Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane. Plays a role in the development of the nervous system, and may be required for neuron projection development. May also play a role during adipose tissue development. Required for maintenance of the ocular lens (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.