mTOR-Exocyst Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes TBCK (TBC-domain kinase regulating mTOR/Rab GTPases), GSK3B (central kinase in PI3K/mTOR/Wnt), and OGT (nutrient-sensing O-GlcNAcylation) together define a nutrient/metabolic signaling axis. EXOC4/EXOC1 encode exocyst complex subunits mediating vesicle docking and secretion. DOCK11 (Rac GEF), STAT1, NRDC, and MYCBP2 (large ubiquitin E3 ligase) add signaling regulatory depth. CTC1, NPAT, SLF2 are peripheral members involved in DNA/chromatin maintenance. The dominant theme is mTOR-pathway metabolic signaling integrated with exocytic vesicle trafficking, consistent with a metabolically active gd T cell state. Uniform expression and low pct positive suggest this program is active in a rare subset rather than a contaminant.
Genes
ANKRD36C, ARFGEF1, CGGBP1, CTC1, DOCK11, EXOC1, EXOC4, FRYL, GSK3B, ITFG2, LRCH3, MYCBP2, NPAT, NRDC, OGT, PIK3R4, SLF2, STAT1, TBCK, TRIM44, VEZF1
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.88
- Actin Cytoskeletal Regulation · correlation 0.87
- Vesicular Trafficking · correlation 0.86
- T Cell Identity Program · correlation 0.84
- DNA Damage Response · correlation 0.84
- ER Antigen Processing · correlation 0.84
- Interferon Stimulated Genes · correlation 0.82
- Chromatin Remodeling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.