JNK/MAPK Stress Signaling
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 28 genes have a known function matching the annotation |
Why this annotation
Three MAPK pathway genes form a clear kinase cascade: MAP3K3 (MEKK3) and MAP3K1 (MEKK1) are MAP3Ks that activate JNK, and MAPK8 encodes JNK1 itself, the terminal stress-activated kinase. PELI2 (Pellino E3 ligase, downstream of TLR/IL-1R/TRAF6) and COP1 (E3 ubiquitin ligase) place ubiquitin-mediated regulation in this stress-signaling context. ELMO1 and its functional partner DOCK topology suggest Rac-mediated cytoskeletal coupling to the JNK pathway. FOXP1 is a lymphocyte transcription factor whose degradation is regulated by JNK signaling. LRRC8C (VRAC anion channel) is activated during osmotic/cellular stress and immune activation. USP3 and UVRAG add DNA damage/autophagy regulation. The module represents a JNK/stress-MAPK signaling program in gd T cells, consistent with activation or environmental stress response. Neighbor modules M46/M81 share the large-gene/low-pct-positive profile and represent related intracellular regulatory states.
Genes
ABTB3, BICRAL, COP1, DICER1, ELMO1, ERC1, FBXO11, FCHSD2, FGFR1, FOXN3, FOXP1, HGSNAT, LRRC8C, MAP3K1, MAP3K3, MAPK8, MEGF9, OGFRL1, PAN3, PDE8A, PELI2, SNX29, SUMF1, TBC1D22A, USP3, UVRAG, WIPI2, ZFAND3
Most correlated modules
- Autophagy & Trafficking · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.