Enteric Glial Identity
Gene co-expression module in Glial cells
| Category | Activation |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
NDRG2 is a highly specific marker of enteric glia (and astrocytes/Müller cells), involved in glial differentiation and stress response. PLEKHB1 is expressed in retinal/neural glia. FAM181B is a brain-enriched gene of unknown function. NKAIN3 interacts with the Na+/K+-ATPase beta subunit and is expressed in neural tissues. RBP7 is a retinol-binding protein expressed in glia involved in lipid metabolism. HTRA1 is a serine protease that cleaves ECM components and is expressed in glia. NDRG2 and FIBIN (fin bud initiation factor homolog, expressed in enteric glia) together define enteric glial identity. FXYD1 (phospholemman) regulates Na+/K+-ATPase in neural/muscle cells. METTL7A is a methyltransferase. MRPS6 encodes a mitochondrial ribosomal protein. The module has the strongest UC inflammation delta (-1.344, sig.) and strong remission recovery (+0.891), pointing to a highly inflammation-sensitive enteric glial identity program. NDRG2 as top hub strongly anchors this to enteric glia.
Genes
FAM181B, FIBIN, FXYD1, HTRA1, METTL7A, MRPS6, NDRG2, NKAIN3, PLEKHB1, RBP7
Most correlated modules
- Glial Identity Homeostasis · correlation 0.86
- Neuroprotective Secretory · correlation 0.77
- Mature Glial Identity · correlation 0.77
- Glial Myelination Identity · correlation 0.77
- Glial Adhesion Cytoskeletal · correlation 0.71
- Glial Synaptic Adhesion · correlation 0.71
- Peripheral Nerve Myelination · correlation 0.70
- Matricellular ECM Homeostasis · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.