Enteric Glial Homeostasis
Gene co-expression module in Glial cells
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
ENTPD2 (NTPDase2) is a canonical enteric glial marker that hydrolyzes extracellular ATP for purinergic signaling. BCHE (butyrylcholinesterase) is expressed by enteric glia and supports neurotransmitter metabolism. APOE is produced by glia for lipid transport and neuroprotection. SCRG1 (scrapie-responsive gene 1) is a glial marker upregulated in reactive glia. NPDC1 (neural proliferation differentiation control 1) and FXYD6 are neural/glial markers. VCAN (versican) and COL12A1 are ECM components of the glial niche. THY1 marks mesenchymal/glial populations. STMN1 marks proliferating/early glia. SOD3 provides extracellular antioxidant defense. This is a homeostatic enteric glial identity module.
Genes
APOE, BCHE, CCND3, COL12A1, ENTPD2, FXYD6, NPDC1, PAQR6, PCSK1N, SCRG1, SOD3, STMN1, THY1, VCAN
Most correlated modules
- ENS Developmental TFs · correlation 0.81
- Mature Glial Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.