Peripheral Nerve Myelination
Gene co-expression module in Glial cells
| Category | Myelination |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
LGI4 (leucine-rich glioma inactivated 4) is a secreted protein essential for peripheral nerve myelination and Schwann cell differentiation. ABCA8 is a lipid transporter highly expressed in Schwann cells and myelin-producing glia. ITGB4 (integrin β4) is a laminin receptor critical for Schwann cell-axon interactions and myelination. NRP2 (neuropilin-2) guides axons and Schwann cells. SYT10 links to calcium-regulated glial secretion. COL27A1 is a fibrillar collagen expressed in peripheral nerves. This module strongly represents a peripheral glial/Schwann cell myelination program in the ENS.
Genes
ABCA8, AKAP12, CIT, COL27A1, ITGB4, LGI4, NRP2, SAMHD1, SYT10
Most correlated modules
- Basement Membrane Adhesion · correlation 0.89
- Glial Adhesion Cytoskeletal · correlation 0.81
- Actin Remodeling Migration · correlation 0.76
- Glial Synaptic Adhesion · correlation 0.75
- RNA Splicing Regulation · correlation 0.75
- Glial RNA Homeostasis · correlation 0.74
- Glial Identity Homeostasis · correlation 0.73
- Neural Migration Scaffold · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.