Mast Cell Activation
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
This module shows mild upregulation in UC inflammation. SAMSN1 is a scaffold/signaling adaptor expressed in hematopoietic cells involved in immune regulation. RUNX3 is a transcription factor critical for immune cell differentiation and mast cell identity. TNFSF10 (TRAIL) is a TNF superfamily cytokine involved in apoptosis and immune regulation. S1PR2 (sphingosine-1-phosphate receptor 2) regulates mast cell retention in tissues. PTAFR (platelet-activating factor receptor) is a key mast cell activation receptor. PLAU (urokinase plasminogen activator) is involved in tissue remodeling and inflammation. cGAS is a cytosolic DNA sensor involved in innate immunity. SUMO4 modulates NF-κB signaling. TOB2 is an anti-proliferative gene. OAZ2 regulates polyamine metabolism. SNRPB2 is an RNA splicing factor. PPIF (cyclophilin D) is involved in mitochondrial permeability. POMP is a proteasome assembly chaperone. The combination of S1PR2, PTAFR, RUNX3, TNFSF10, and SAMSN1 suggests a mast cell tissue-residency and immune activation program, with some apoptotic/stress components.
Genes
Most correlated modules
- Chromatin Transcriptional Regulation · correlation 0.81
- Inflammatory Mast Activation · correlation 0.80
- Proteostasis & Translation · correlation 0.79
- Mixed Splicing Stress · correlation 0.76
- Housekeeping Maintenance · correlation 0.74
- Protein Biogenesis Housekeeping · correlation 0.71
- Co-transcriptional RNA Processing · correlation 0.68
- Mast Cell Degranulation · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.