Autophagy Stress Response
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 32 genes have a known function matching the annotation |
Why this annotation
MAP1LC3A (LC3A) is a core autophagosome component and definitive autophagy marker. HIGD1A is a hypoxia-inducible gene that promotes mitochondrial survival and is upregulated during mitophagy. CASP9 is an initiator caspase in the intrinsic apoptosis pathway. RIPK2 is a kinase in NOD1/2 innate immune signaling. DUSP10 is a stress-activated MAPK phosphatase. PRKAR1A is a PKA regulatory subunit. CCS is a copper chaperone for SOD1 (oxidative stress). The module is upregulated in UC inflammation. The combination of autophagy (MAP1LC3A, HIGD1A), apoptosis (CASP9), and innate immune signaling (RIPK2) suggests a stress-induced autophagy/cell survival program in inflamed mast cells.
Genes
Most correlated modules
- LXR/PPAR Repression · correlation 0.91
- Innate Immune Stress · correlation 0.88
- Mediator-Integrator Transcription · correlation 0.87
- NF-κB Activation · correlation 0.86
- Telomere Maintenance · correlation 0.84
- Mast Cell Activation · correlation 0.84
- NF-κB Immediate Response · correlation 0.83
- Hypoxia Stress Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.