Mitochondrial Respiratory Complex
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include BCAS2 (spliceosome component), YBX3 (Y-box binding protein, transcription/RNA regulation), DDX24 (RNA helicase), UQCRFS1 (mitochondrial complex III subunit, Rieske iron-sulfur protein), ETFRF1 (electron transfer flavoprotein regulatory factor, mitochondrial), CDC42 (Rho GTPase, cytoskeletal), DYNLT3 (dynein light chain), and CHMP1B (ESCRT-III). The module is mixed: mitochondrial respiratory chain (UQCRFS1, ETFRF1), RNA processing (BCAS2, YBX3, DDX24), and cytoskeletal (CDC42, DYNLT3). The strongest negative remission correlation (delta_remission_UC=-1.074) among this batch suggests disease relevance. The mitochondrial components (UQCRFS1, ETFRF1) are the most functionally coherent sub-group, but the module is genuinely mixed. Given the mitochondrial hub genes and the neighbor context (M197 UPR, M113 with OxPhos genes), a mitochondrial/metabolic label is most supported.
Genes
Most correlated modules
- Hypoxia Stress Response · correlation 0.91
- Transcription & Splicing · correlation 0.87
- RAS/MAPK Signaling · correlation 0.85
- Splicing & Transcription · correlation 0.82
- General Housekeeping · correlation 0.81
- NF-κB Activation · correlation 0.80
- mRNA Processing · correlation 0.78
- Telomere Maintenance · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.