Mediator-Integrator Transcription
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include ADNP2 (chromatin remodeling, SWI-SNF associated), MED21 (Mediator complex subunit, transcription co-activator), KAT5 (TIP60 histone acetyltransferase, chromatin regulation and DNA damage response), CNOT9 (CCR4-NOT deadenylase complex, mRNA decay and transcription), INTS12 (Integrator complex, RNA Pol II regulation), CSTF1 (cleavage and polyadenylation), SLU7 (pre-mRNA splicing), BCOR (transcriptional repressor, Polycomb-associated), DDIT3 (CHOP, ER/integrated stress response transcription factor), NFAT5 (osmotic stress-responsive transcription factor), DNAJB2 (chaperone). This module represents a transcriptional co-regulatory program involving Mediator, Integrator, and chromatin-modifying complexes, with stress-responsive transcription factors (DDIT3, NFAT5) as peripheral members. Neighbor M42 has immediate-early AP-1 genes; this module represents the upstream transcriptional machinery.
Genes
Most correlated modules
- Autophagy Stress Response · correlation 0.87
- Hypoxia Stress Response · correlation 0.82
- LXR/PPAR Repression · correlation 0.82
- RNA & Protein Homeostasis · correlation 0.79
- mRNA Processing · correlation 0.78
- Telomere Maintenance · correlation 0.78
- Mitochondrial Respiratory Complex · correlation 0.75
- Endosomal Vesicle Trafficking · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.