Transcription & Splicing
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 30 genes have a known function matching the annotation |
Why this annotation
Top hub CHD2 is a chromatin remodeling helicase; SMARCA5 is a SWI/SNF ATPase; POLR3E and POLR1F are RNA polymerase III and I subunits; TAF7 is a TFIID general transcription factor. SF3B1, RBM27, RBM39, FIP1L1, SMU1 are all pre-mRNA splicing factors. ZEB2 and ETV6 are transcription factors. BCL2L13 is a mitochondrial apoptosis regulator. The module is dominated by transcriptional regulation and RNA splicing machinery. Significant increase with CD inflammation suggests heightened transcriptional activity in inflamed mast cells. Neighbor modules M103 (SRSF5, SF1, RAVER1) and M202 (SMARCE1) share splicing/chromatin themes.
Genes
Most correlated modules
- Cytoskeletal Adhesion Signaling · correlation 0.89
- Mitochondrial Respiratory Complex · correlation 0.87
- Telomere Maintenance · correlation 0.86
- RAS/MAPK Signaling · correlation 0.84
- NF-κB Activation · correlation 0.84
- General Housekeeping · correlation 0.84
- LXR/PPAR Repression · correlation 0.83
- mRNA Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.