General Housekeeping
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 21 genes have a known function matching the annotation |
Why this annotation
This module contains a heterogeneous mix of housekeeping genes: CSNK1A1 (casein kinase 1α, ubiquitin-proteasome/Wnt), FTH1 (iron storage/ferritin), SEC62 (ER protein translocation), ATP6V1G1 (V-ATPase subunit), TUBGCP2 (gamma-tubulin complex, microtubule nucleation), ANAPC16 (APC/C ubiquitin ligase complex), PPP3CA (calcineurin phosphatase), PJA2 (E3 ubiquitin ligase), OXSR1 (osmotic stress kinase), MIER1 (transcriptional repressor), CEBPZ (transcription factor). The module reflects general cellular maintenance processes including protein turnover, iron homeostasis, and cytoskeletal organization. Moderate expression and broad detection are consistent with housekeeping activity.
Genes
Most correlated modules
- Cytoskeletal Adhesion Signaling · correlation 0.85
- MAPK-AP1 Signaling · correlation 0.85
- Transcription & Splicing · correlation 0.84
- RAS/MAPK Signaling · correlation 0.83
- NF-κB Activation · correlation 0.83
- NF-κB Inflammatory Signaling · correlation 0.81
- Mitochondrial Respiratory Complex · correlation 0.81
- Autophagy Stress Response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.