Mast Cell Specification
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
FLI1 is a master transcription factor for mast cell and hematopoietic development. NOTCH2 drives mast cell fate decisions. WAS (Wiskott-Aldrich) is critical for mast cell function and actin remodeling. CREBBP and NCOA6 are transcriptional coactivators involved in lineage specification. PGAP3 is involved in GPI anchor biosynthesis relevant to mast cell surface proteins. MBNL3 regulates RNA splicing in hematopoietic cells. The module is enriched for transcriptional regulators of mast cell identity and development. Neighbor context (M115 has KIT/SIGLEC6) supports a developmental program here.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.95
- RAS/Rho GTPase Signaling · correlation 0.94
- PI3K Inflammatory Signaling · correlation 0.93
- Mast Cell Homeostasis · correlation 0.93
- Chromatin Remodeling · correlation 0.93
- Mast Cell Identity · correlation 0.92
- Vesicle ER Trafficking · correlation 0.92
- Circadian Clock Regulation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.