Ubiquitin-Lysosomal Maintenance
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include OTUB1 (deubiquitinase), PSAP (lysosomal prosaposin), CAPNS1 (calpain regulatory subunit), PPP2R1A (PP2A scaffold subunit), CNBP (zinc finger protein), and RNF187 (E3 ubiquitin ligase). Together these represent general cellular maintenance functions including ubiquitin-proteasome regulation, lysosomal activity, and protein phosphatase signaling. Expression is uniform across subsets with moderate mean, consistent with housekeeping activity. No strong disease association.
Genes
Most correlated modules
- Calcium-GPCR Signaling · correlation 0.92
- Cytoskeletal Remodeling · correlation 0.91
- Glucocorticoid Stress Response · correlation 0.90
- Lysosomal Autophagy · correlation 0.89
- Housekeeping Signaling · correlation 0.89
- Mast Cell Identity · correlation 0.89
- Chromatin Remodeling · correlation 0.88
- mTOR-Cytoskeletal Regulation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.