JAK-TEC Signaling
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include JAK2 (cytokine receptor-associated kinase critical for mast cell signaling), TEC (Tec-family kinase essential for mast cell activation), MYO18A and ADD1 (cytoskeletal regulators), SSH3 (slingshot phosphatase, actin dynamics), MAML3 (Notch co-activator), FBXL17 (ubiquitin E3 ligase), ANKRD27 (vesicle trafficking/VARP), and CAPN7 (calpain protease). The module is uniformly expressed at low levels with no subset enrichment, suggesting a broadly active regulatory program. JAK2 and TEC together point toward mast cell receptor signaling scaffolding. The module is a mixed regulatory/signaling housekeeping program; JAK2 and TEC are the most biologically specific anchors for mast cell identity. Mild positive delta_inflammation scores are consistent with signaling pathway upregulation in IBD.
Genes
Most correlated modules
- Rho GTPase Signaling · correlation 0.94
- RAS/Rho GTPase Signaling · correlation 0.93
- Mast Cell Identity · correlation 0.92
- Calcium Store Signaling · correlation 0.91
- PI3K Inflammatory Signaling · correlation 0.91
- PD-L1 Checkpoint Program · correlation 0.89
- Mast Cell Specification · correlation 0.88
- Mast Cell Identity · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.