Mast Cell Identity
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes IKZF1 (Ikaros TF essential for mast cell/lymphoid development), LCP2 (SLP-76, immune receptor signaling adapter), CD53 (leukocyte surface antigen), LPCAT2 (lysophosphatidylcholine acyltransferase 2, active in mast cells), RAB5B (endosomal trafficking), RASA2 (RAS-GAP, signal termination), PRPS2 (purine biosynthesis), KIDINS220 (kinase D-interacting substrate, neurotrophin/immune signaling) collectively point to a mast cell homeostatic identity and immune signaling program. IKZF1 and LCP2 are particularly strong anchors for mast cell identity and receptor-proximal signaling. The module is decreased in UC remission, consistent with active mast cell presence during inflammation.
Genes
Most correlated modules
- Mast Cell Specification · correlation 0.95
- TGF-beta Tolerance · correlation 0.94
- Mast Cell Identity · correlation 0.94
- NF-κB Signaling · correlation 0.93
- Glucocorticoid Stress Response · correlation 0.93
- Mast Cell Homeostasis · correlation 0.92
- PI3K Inflammatory Signaling · correlation 0.92
- Epigenetic Transcriptional Control · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.