Glucocorticoid Stress Response
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 25 genes have a known function matching the annotation |
Why this annotation
Key hub genes FKBP5, FOXO3, and KLF9 are all well-established glucocorticoid-responsive genes. GSTM2 and GSTM3 are glutathione S-transferases involved in oxidative stress detoxification. PIK3IP1 inhibits PI3K/AKT signaling downstream of stress. CCND3 is regulated by FOXO3. The module is significantly upregulated in UC inflammation and decreases with remission, consistent with a stress/glucocorticoid response program activated during inflammation. STARD13 and FOXO3 also link to oxidative stress pathways.
Genes
Most correlated modules
- Calcium-GPCR Signaling · correlation 0.95
- Mast Cell Identity · correlation 0.95
- NF-κB Signaling · correlation 0.94
- Mast Cell Homeostasis · correlation 0.94
- Transcriptional Metabolic Regulation · correlation 0.94
- Cytoskeletal Remodeling · correlation 0.93
- Mast Cell Identity · correlation 0.93
- Chromatin Remodeling · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.