Calcium Store Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
STIM1 is the master sensor of ER calcium store depletion and drives store-operated calcium entry (SOCE), critical for mast cell activation and degranulation. UVRAG and WASHC2C participate in endosomal trafficking/autophagy. ARFGEF2 and MON2 regulate Golgi/endosomal vesicle dynamics. TAB3 links to TAK1-NF-kB signaling. DIABLO is a mitochondrial pro-apoptotic factor. UBA7 is the E1 for ISG15. The module is significantly upregulated in UC inflammation and reversed in remission, consistent with calcium-driven mast cell activation in colitis. CLASP2 stabilizes microtubules during secretory vesicle transport.
Genes
Most correlated modules
- RAS/Rho GTPase Signaling · correlation 0.94
- Rho GTPase Signaling · correlation 0.94
- Circadian Clock Regulation · correlation 0.93
- Mast Cell Identity · correlation 0.92
- Purinergic Receptor Signaling · correlation 0.91
- JAK-TEC Signaling · correlation 0.91
- Inflammatory IRAK3-BATF Response · correlation 0.91
- Mitochondrial Fusion Stress · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.