Inflammatory IRAK3-BATF Response
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
This module is significantly upregulated in both UC and CD inflammation (delta_inflammation_UC=1.302 sig., delta_inflammation_CD=0.817 sig.) and suppressed in UC remission. Key immune genes: IRAK3/IRAK-M (negative regulator of TLR/IL-1R signaling, induced during inflammation to dampen responses), BATF (AP-1 family transcription factor critical for mast cell and immune cell activation), TNFRSF21/DR6 (death receptor 6, TNF superfamily). KIF13B mediates vesicle transport. ALDOA (glycolysis upregulation in inflammation). ELOVL5 (fatty acid elongation). MATR3 (nuclear matrix protein). NUP98 (nucleoporin, nuclear transport). The combination of IRAK3 and BATF with significant inflammation association suggests a mast cell inflammatory response module with negative feedback (IRAK3) and transcriptional activation (BATF).
Genes
Most correlated modules
- Circadian Transcription · correlation 0.95
- Cytoskeletal Remodeling · correlation 0.94
- Transcriptional Metabolic Regulation · correlation 0.93
- ER Protein Quality Control · correlation 0.93
- Calcium Store Signaling · correlation 0.91
- Purinergic Receptor Signaling · correlation 0.90
- Autophagy Lysosomal Program · correlation 0.90
- NF-κB Stress Signaling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.