MARCH Ubiquitin Ligase
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
The top hub genes are MARCHF8 and MARCHF7, membrane-associated RING-CH E3 ubiquitin ligases that ubiquitinate and downregulate immune receptors including MHC-I, FcεRI, and CD86, thereby modulating immune activation. SRCAP (H2A.Z chromatin remodeling), ATXN7 (SAGA deubiquitinase module), CERT1 (ceramide transfer protein), TAFAZZIN (cardiolipin remodeling), ARF5 (Golgi ARF GTPase), ATG9A (autophagy initiation), and GOLM2 (Golgi) support membrane/lipid trafficking and chromatin contexts. The MARCH ligases are the strongest signal and are known to regulate immune receptor surface expression in mast cells and other immune cells. Upregulated in CD inflammation.
Genes
Most correlated modules
- RNA Processing & Mitochondrial · correlation 0.94
- Lysosomal Autophagy · correlation 0.92
- Protein Homeostasis · correlation 0.92
- Aminoacyl-tRNA Synthetase · correlation 0.90
- Ubiquitin-Chromatin Regulation · correlation 0.89
- NF-κB Stress Signaling · correlation 0.89
- tRNA Aminoacylation · correlation 0.88
- Histone Variant Chromatin · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.