ER-Mitochondria Homeostasis
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include TXNDC11 (thioredoxin domain, ER redox), MSH5 (DNA mismatch repair, meiotic recombination), PDZD8 (ER-mitochondria tethering), RC3H1 (Roquin, mRNA decay regulator), SLC25A25 (mitochondrial ATP-Mg/Pi carrier), TRAPPC10 (TRAPP vesicle tethering complex), ACAP2 (Arf1 GAP, vesicle trafficking), NRROS (LRRC33, TGF-β presentation/regulation), PCNT (pericentrin, centrosome). The module is small (9 genes) with strong/core membership. Increased with UC inflammation. No single tight pathway; the most coherent theme across PDZD8, SLC25A25, TXNDC11 is ER-mitochondria interface and redox/metabolic homeostasis, with RC3H1 adding post-transcriptional regulation. This is a mixed low-coherence module best described as ER-mitochondria homeostasis.
Genes
Most correlated modules
- Rho GTPase Signaling · correlation 0.90
- General Cellular Maintenance · correlation 0.89
- Calcium Store Signaling · correlation 0.88
- JAK-TEC Signaling · correlation 0.87
- Cytoskeletal Organization · correlation 0.85
- Integrin-Calcium Signaling · correlation 0.85
- UPR Secretory Stress · correlation 0.85
- RNA & Membrane Housekeeping · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.