DNA Damage Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes ATM and PARP1 are canonical DNA damage response kinases/enzymes. MEF2C is a key myeloid transcription factor regulating monocyte/macrophage identity. TLR5 contributes innate immune sensing. XPO1 mediates nuclear export of stress-response factors. NSL1 and PRKACB add kinetochore and PKA signaling components. The module is core-coherent and uniformly expressed, with upregulation in inflammation and downregulation in remission, consistent with a DNA damage/stress-sensing program active in inflammatory monocytes.
Genes
AGPAT5, ATM, CALM2, DCAF7, FAM13A, GPR155, MEF2C, NLN, NSL1, PARP1, PRKACB, TLR5, XPO1
Most correlated modules
- Macrophage Innate Activation · correlation 0.79
- GIMAP activation · correlation 0.77
- M2 Macrophage Polarization · correlation 0.74
- IL-18 Inflammasome Response · correlation 0.72
- Tissue Macrophage Identity · correlation 0.72
- Tissue-Resident Macrophage · correlation 0.71
- Biosynthetic Metabolic Activation · correlation 0.64
- CCR2+ Monocyte Identity · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.