Innate Immune Transcription
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
ELF4 (MEF) is an ETS transcription factor that activates innate immune genes including type I IFN and NF-κB targets in monocytes. CARD19 contains a caspase recruitment domain involved in innate immune signaling. ZFYVE9 (SARA) is a FYVE-domain protein that facilitates TGF-β/SMAD2 signaling and endosomal trafficking. PCIF1 is an m6A cap methyltransferase that modifies mRNA and regulates innate immune gene expression. CSNK1E (casein kinase 1 epsilon) regulates Wnt/circadian pathways. COG3 is a Golgi trafficking component. EXTL3 is involved in heparan sulfate biosynthesis affecting cytokine signaling. The module is upregulated in IBD inflammation, with ELF4 and CARD19 as the strongest innate immunity anchors.
Genes
CARD19, COG3, CSNK1E, ELF4, EXTL3, PCIF1, RBM38, SMIM3, ZFYVE9
Most correlated modules
- MET Tissue Repair · correlation 0.87
- Endosomal Sorting · correlation 0.84
- Inflammatory Autophagy · correlation 0.82
- Autophagy Initiation · correlation 0.81
- Secretory Vesicle Trafficking · correlation 0.80
- AMPK-FOXO Stress Response · correlation 0.76
- Glucocorticoid Transcription · correlation 0.66
- Myeloid Epigenetic Regulation · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.