Mitochondrial/ER housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
The module contains mitochondrial carriers and assembly factors (SLC25A12, SLC25A53, NDUFAF6), ER/GPI genes (LNPK, PIGF), mRNA export (GLE1), and the hypoxia regulator HIF1AN. Several zinc-finger and NBPF genes are also present. It is heterogeneous with uniform expression, and the weak mitochondrial theme does not form a strong program. It is best treated as housekeeping.
Genes
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.91
- Nuclear regulator transcripts · correlation 0.83
- Transcriptional elongation · correlation 0.80
- Ribosome biogenesis · correlation 0.79
- Transcription/RNA processing · correlation 0.77
- Basal housekeeping mix · correlation 0.77
- IFN-inducible myeloid mix · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.