Resting myeloid homeostasis
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
Mixed, low-expression module. P2RY12, LPAR6 and NOD1 suggest a resting or homeostatic tissue-resident myeloid tone. The remaining genes are diverse housekeeping genes (COA1, CMC2, RNASEH2B, AGPAT5), giving no clear program. Its link to the neighboring modules is likely a shared baseline cell state.
Genes
Most correlated modules
- Basal endolysosomal maintenance · correlation 0.94
- BTN3A immunoregulatory · correlation 0.90
- Membrane trafficking housekeeping · correlation 0.86
- Generic transcriptional housekeeping · correlation 0.84
- Generic gene-expression machinery · correlation 0.84
- Nuclear RNA processing · correlation 0.83
- Integrin-mediated recruitment · correlation 0.82
- Type I Interferon · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.