Membrane trafficking housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes (BLTP1, RAB3GAP1, CDK17, ETNK1, SRGAP2/2B, STK24, AGPAT3, PRKCE, OSBPL5, SYNJ1, EFR3A, RABGAP1L, RUBCN) are long, broadly expressed genes. They span lipid transfer, phosphoinositide metabolism, Rab GTPase regulation and endocytosis, with no single dominant pathway. Expression is uniform and high (62% positive), consistent with a transcript-length or nuclear-retained housekeeping signature. A subset of genes points to membrane and vesicle trafficking (RAB3GAP1, RABGAP1L, SYNJ1, EFR3A, OSBPL5, BLTP1, RUBCN). TBK1 and RIPK1 offer a weak link to neighboring innate signaling modules.
Genes
Most correlated modules
- Basal endolysosomal maintenance · correlation 0.87
- Resting myeloid homeostasis · correlation 0.86
- Nuclear RNA processing · correlation 0.84
- BTN3A immunoregulatory · correlation 0.80
- NF-kB feedback regulation · correlation 0.79
- Chromatin transcription regulators · correlation 0.79
- IFN-induced antiviral autophagy · correlation 0.78
- Myeloid Immunoreceptor Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.