Generic transcriptional housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes ZNF710, TBC1D22A, ATR, ASCC3, YTHDC2 and WDR70 are a heterogeneous mix of long, ubiquitously expressed genes spanning DNA damage signaling, RNA helicase activity, vesicle trafficking (RABEP1, TBC1D22A) and phosphoinositide metabolism (PIP4K2A, ITPK1). Expression is uniform and broadly detected, with no specific program. Its neighbors are equally nonspecific housekeeping modules, which supports reading this as a gene-length/transcriptional-capacity covariation axis rather than a biological state. A minor DNA damage response flavor is present (ATR, ASCC3, WDR70, MAD1L1).
Genes
Most correlated modules
- Generic gene-expression machinery · correlation 0.92
- Generic housekeeping metabolism · correlation 0.92
- Long-gene housekeeping · correlation 0.91
- Nuclear RNA processing · correlation 0.90
- Integrin-mediated recruitment · correlation 0.89
- Small GTPase signaling · correlation 0.89
- mRNA processing/export · correlation 0.88
- KZFP/housekeeping transcripts · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.