Non-classical Monocyte State
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
MS4A7 is a canonical non-classical monocyte marker. FAM162A is induced by hypoxia and promotes apoptosis. CTSC (cathepsin C) is a lysosomal cysteine protease active in monocytes/macrophages. TUBA1B and TUBB are tubulin subunits. SLC3A2 is a large neutral amino acid transporter upregulated in activated cells. SLC25A33 is a mitochondrial pyrimidine nucleotide transporter. CAMK1D is a calcium/calmodulin kinase. NBDY regulates P-bodies and mRNA decay. The module combines non-classical monocyte identity (MS4A7), lysosomal activity (CTSC), and metabolic/hypoxic adaptation (FAM162A, SLC3A2). Up in inflammation, down in remission.
Genes
CAMK1D, CTSC, FAM162A, MS4A7, NBDY, SLC25A33, SLC3A2, TUBA1B, TUBB
Most correlated modules
- Non-classical Monocyte · correlation 0.84
- Biosynthetic Metabolic Activation · correlation 0.82
- Mitochondrial Immune Regulation · correlation 0.82
- Tissue Macrophage Identity · correlation 0.81
- MHC II Antigen Presentation · correlation 0.81
- Macrophage Differentiation · correlation 0.77
- Monocyte Lipid Handling · correlation 0.77
- Autophagy Metabolic Stress · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.