Chromatin modifier transcripts
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
The hubs are long, ubiquitously expressed chromatin regulators: ASH1L, SETD2, KDM2A, JMJD1C and TET2. Alongside them sit RNA-binding proteins (PUM1, QKI, TRA2A) and ubiquitin/SUMO enzymes (USP34, PIAS1, RNF216). Expression is uniform with high detection, a pattern typical of a long-gene, nuclear-transcript and intronic-read program rather than a cell-state program. Neighboring modules share the same character (splicing factors, chromatin regulators), supporting a housekeeping/technical nuclear-transcript axis. Here the dominant theme is epigenetic chromatin modifiers.
Genes
Most correlated modules
- Microtubule organization · correlation 0.95
- Ubiquitin ligase housekeeping · correlation 0.93
- Transcriptional coregulators · correlation 0.90
- ER secretory housekeeping · correlation 0.90
- Pre-mRNA splicing · correlation 0.90
- Myeloid regulatory autophagy · correlation 0.90
- SYK-Rac actin signaling · correlation 0.90
- Chromatin repression housekeeping · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.