Proteasome/proteostasis
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 33 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence mix contains proteasome subunits (PSMD2, PSMB7, PSMC1), cytoskeletal regulators (ARHGDIA, PARVG, ARPC4), mitochondrial genes (PRDX3, NDUFS2, COA5), ER stress (TMBIM6), chaperone (DNAJC7) and SUMOylation (UBE2I). Proteostasis/proteasome is the most coherent sub-theme.
Genes
Most correlated modules
- mRNA Splicing · correlation 0.86
- Translation/biosynthetic capacity · correlation 0.82
- Lysosomal/late endosome · correlation 0.82
- Mitochondrial complex I · correlation 0.81
- ER Unfolded Protein Response · correlation 0.80
- Ribosome biogenesis · correlation 0.79
- Translation initiation · correlation 0.75
- Monocyte-macrophage differentiation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.