Inflammatory Monocyte Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
CCR1 is a chemokine receptor for CCL3/CCL5 mediating monocyte recruitment; IFI16 is an IFN-inducible DNA sensor; JAK2 is a kinase in cytokine signaling; BACH1 is a transcriptional repressor of heme oxygenase and inflammatory genes; DAPP1 is a B-cell/myeloid adaptor; AQP9 is a water/glycerol channel expressed in inflammatory monocytes; DUSP6 is a MAPK phosphatase; FYB1 is an actin-binding adaptor in immune cells. The module shows moderate coherence and mild upregulation in inflammation. The combination of CCR1, IFI16, JAK2, and AQP9 points to inflammatory monocyte activation/recruitment. As a neighbor to the IFN modules, IFI16 and JAK2 link this to IFN signaling, but CCR1 and AQP9 indicate a broader inflammatory monocyte state.
Genes
AQP9, BACH1, CCR1, DAPP1, DUSP6, FYB1, IFI16, JAK2
Most correlated modules
- Inflammasome Activation · correlation 0.80
- IRF1 Innate Activation · correlation 0.78
- JAK-STAT IFN Signaling · correlation 0.78
- AP-1 Stress Response · correlation 0.73
- IFN-gamma Response · correlation 0.71
- Macrophage Innate Activation · correlation 0.71
- Fc Receptor Activation · correlation 0.66
- Inflammasome Activation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.