Integrated Stress Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
EIF2AK3 (PERK, ER stress kinase of the integrated stress response), MAFF (oxidative/electrophilic stress bZIP TF), CSRNP1 (stress-responsive transcriptional repressor), TIPARP (PARP7, AhR/stress response), CDKN1A (p21, stress-induced cell cycle arrest), PIM3 (pro-survival kinase), HBEGF (stress-induced growth factor), KLF10 (TGF-β/stress TF). This is a tightly coherent integrated stress response module, significantly upregulated in IBD inflammation and reduced in remission.
Genes
CDKN1A, CSRNP1, EIF2AK3, HBEGF, KLF10, MAFF, PIM3, TIPARP
Most correlated modules
- Hypoxia Response · correlation 0.67
- Non-canonical NF-κB · correlation 0.64
- Inflammatory Autophagy · correlation 0.62
- AMPK-FOXO Stress Response · correlation 0.60
- Wnt/AP-1 Activation · correlation 0.56
- Endosomal Sorting · correlation 0.52
- Glucocorticoid Transcription · correlation 0.51
- G-protein Membrane Remodeling · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.