RNA Processing/Translation
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Genes are a heterogeneous mix of general cellular machinery: RNA-binding/splicing (NONO, SERBP1, KHDRBS1, SF3A3, LSM12), ER translocation (SRP72, TRAM1), translation (EIF3J, EIF2A), and metabolism (CS, NDUFS4). This pattern reflects general housekeeping/biosynthetic capacity rather than a specific monocyte program. It co-varies with neighboring growth modules.
Genes
Most correlated modules
- mRNA Splicing · correlation 0.93
- Nucleolar Ribosome Biogenesis · correlation 0.91
- Mitochondrial translation/metabolism · correlation 0.91
- General cellular maintenance · correlation 0.90
- Nuclear housekeeping transcripts · correlation 0.89
- ER Unfolded Protein Response · correlation 0.87
- Ribosome Biogenesis · correlation 0.86
- Translation initiation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.