IFN-γ Monocyte Response
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
CXCL9 is a hallmark IFN-γ-induced chemokine attracting T cells and NK cells. SUCNR1 (succinate receptor) is upregulated on inflammatory macrophages/monocytes sensing metabolic danger signals. IL2RA and IL2RG encode IL-2 receptor subunits indicating cytokine-driven activation. APOL3 and ANKRD22 are interferon-stimulated genes. ATF5 and NFE2L3 are stress-responsive transcription factors. This module reflects IFN-γ-driven monocyte activation with metabolic inflammation sensing in IBD.
Genes
ANKRD22, APOL3, ATF5, CXCL9, HAPLN3, IL2RA, IL2RG, LYSMD2, NFE2L3, PPA1, SUCNR1
Most correlated modules
- Tolerogenic Monocyte Activation · correlation 0.91
- Inflammasome Activation · correlation 0.82
- IFN-gamma Response · correlation 0.81
- Inflammasome Activation · correlation 0.78
- IRF1 Innate Activation · correlation 0.74
- NF-κB Counter-regulation · correlation 0.74
- MHC-II Antigen Presentation · correlation 0.72
- SPP1+ Inflammatory Macrophage · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.