CCR2+ Monocyte Identity
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
CCR2 is the defining chemokine receptor of classical inflammatory monocytes; MNDA (myeloid nuclear differentiation antigen) is a classical monocyte marker; LYST controls lysosomal trafficking and is essential for monocyte/macrophage function; TRAF3IP3 modulates TRAF3-dependent innate immune signaling; MAP3K1 feeds into MAPK cascades; RGS18 regulates G-protein signaling downstream of chemokine receptors; VNN1 supports monocyte tissue migration. The module is significantly elevated in both UC and CD inflammation and reduced in remission, consistent with CCR2+ classical monocyte recruitment.
Genes
CCR2, GAPT, LYST, MAP3K1, MNDA, POU2F2, RGS18, SLC24A4, TMEM154, TMPO, TNRC6B, TRAF3IP3, VNN1
Most correlated modules
- p38 MAPK Signaling · correlation 0.76
- Macrophage Innate Activation · correlation 0.71
- DNA Damage Response · correlation 0.63
- Monocyte-DC Differentiation · correlation 0.62
- FPR1 Innate Sensing · correlation 0.59
- GIMAP activation · correlation 0.53
- Tissue-Resident Macrophage · correlation 0.50
- Classical Monocyte Trafficking · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.