Classical Monocyte Trafficking
Gene co-expression module in Monocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
SELL (CD62L) is a canonical classical monocyte trafficking marker; MAP2K6 is the direct upstream kinase of MAPK14/p38 (linking to neighbor M86); PADI4 mediates citrullination and NET-like programs; RAB27A controls secretory vesicle exocytosis; ANXA6 is involved in calcium-dependent membrane dynamics; F5 links to coagulation; MSRB1 provides oxidative stress protection. SELL and EMB together mark classical monocyte identity. The module is elevated in IBD inflammation and reduced in remission, consistent with classical monocyte activation and trafficking.
Genes
ANXA6, CKAP4, EMB, F5, GCA, MAP2K6, MPP7, MSRB1, PADI4, RAB27A, SELL, TDRD9, TSPAN2
Most correlated modules
- Leukotriene-Alarmin Response · correlation 0.86
- p38 MAPK Signaling · correlation 0.83
- Pentose Phosphate Pathway · correlation 0.78
- BPI Antibacterial Response · correlation 0.78
- Classical Monocyte Activation · correlation 0.76
- Monocyte Innate Surveillance · correlation 0.76
- Myeloid Activation · correlation 0.69
- Granulocytic Differentiation · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.