Patrolling Monocyte Cytoskeleton
Gene co-expression module in Monocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 25 genes have a known function matching the annotation |
Why this annotation
TCF7L2 and MTSS1 are hallmark transcripts of non-classical monocytes. They co-occur with actin/membrane-raft and cytoskeletal regulators: PAG1, RFTN1, HEG1, FMNL2, TAGLN and MTPN. Together these suggest the cytoskeletal/adhesion machinery of patrolling CD16+ monocytes that crawl along endothelium. This module neighbors M2 and M3, supporting assignment to the patrolling monocyte state.
Genes
Most correlated modules
- CD16 Monocyte Signature · correlation 0.97
- Actin-endocytic remodeling · correlation 0.95
- NF-kB Myeloid Activation · correlation 0.94
- Non-classical Monocyte Identity · correlation 0.93
- Classical monocyte identity · correlation 0.92
- Mitochondrial-biogenesis housekeeping · correlation 0.92
- Nonclassical monocyte identity · correlation 0.90
- Signaling housekeeping · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.