NF-kB Myeloid Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 19 genes have a known function matching the annotation |
Why this annotation
The hub genes form a myeloid identity and activation program. SPI1 (PU.1), LYN, ADGRE1 and CYTIP mark myeloid identity and signaling. NFKBIZ, BCL2A1 and PTGER4 are NF-kB/TLR-inducible activation and survival genes. SLC2A6 is the glucose transporter of inflammatory macrophages. CMTM6 regulates PD-L1 stability. RAP1B, VASP and MSN mediate integrin and actin signaling. Coherence is core and expression is uniform across subsets, so this reflects a broadly shared, mildly activated monocyte state rather than contamination. It neighbors M171, which is also myeloid kinase signaling, so both describe monocyte signaling.
Genes
Most correlated modules
- Patrolling Monocyte Cytoskeleton · correlation 0.94
- CD16 Monocyte Signature · correlation 0.92
- Actin-endocytic remodeling · correlation 0.89
- Actin Cytoskeleton Dynamics · correlation 0.88
- Classical monocyte identity · correlation 0.88
- Non-classical Monocyte Identity · correlation 0.88
- Mitochondrial-biogenesis housekeeping · correlation 0.86
- Myeloid Immunoreceptor Signaling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.