Immediate Early Response
Gene co-expression module in Neutrophils
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All top hub genes are canonical immediate-early genes (IEGs): IER2, BTG2, JUNB, DUSP1, ZFP36, FOS, EGR1. These are rapidly induced transcription factors and mRNA-destabilizing proteins characteristic of the immediate-early gene response to stimulation or dissociation stress. ADM (adrenomedullin) fits as a stress-responsive gene. Uniform expression across subsets and the core coherence of all members is consistent with a dissociation/handling stress artifact or rapid activation response. Given the neutrophil context and uniform distribution, this is most parsimoniously the immediate-early/dissociation stress response. Neighboring modules (M46, M50) also contain stress-responsive transcription factors (FOSB, KLF2, KLF6), supporting a stress/activation program cluster.
Genes
ADM, BTG2, DUSP1, EGR1, FOS, IER2, JUNB, ZFP36
Most correlated modules
- Inflammasome IL-1 Response · correlation 0.77
- Neutrophil Survival Program · correlation 0.73
- NF-κB Activation · correlation 0.70
- Myeloid Inflammatory Activation · correlation 0.64
- Interferon Stimulated Genes · correlation 0.64
- Neutrophil Adhesion Signaling · correlation 0.62
- Myeloid Identity · correlation 0.62
- Inflammatory Resolution · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.