NF-κB Signaling

Gene co-expression module in Neutrophils

Why this annotation

The hub gene MAML2 is a transcriptional co-activator (Notch pathway), IRAK2 is a key mediator of IL-1R/TLR signaling driving NF-κB activation, PRKCH is a PKC isoform involved in inflammatory signal transduction, HIVEP2 is an NF-κB-binding transcription factor, FLT1 (VEGFR1) is a receptor involved in angiogenic and myeloid signaling, BMP6 is a TGF-β superfamily ligand, DOCK4 is a GEF involved in cytoskeletal/adhesion signaling, RAB20 is involved in vesicular trafficking/endosomal sorting, KIFC3 is a kinesin motor, ATP13A3 is a polyamine transporter, and DSE is a dermatan sulfate epimerase. The module is uniformly expressed with low pct positive (~17%), suggesting a subpopulation-level transcriptional program. The combination of IRAK2, PRKCH, HIVEP2, and MAML2 strongly points to an NF-κB/TLR-driven transcriptional activation program. FLT1 and BMP6 add a cytokine/growth factor signaling layer. Overall, this module reflects a TLR/NF-κB-driven inflammatory gene regulation program in a subset of neutrophils.

Genes

ATP13A3, BMP6, DOCK4, DSE, FLT1, HIVEP2, IRAK2, KIFC3, MAML2, PRKCH, RAB20

Most correlated modules

• Neutrophil Adhesion Signaling · correlation 0.85
• NF-κB Inflammatory Transcription · correlation 0.80
• NF-κB Activation · correlation 0.70
• Myeloid Inflammatory Activation · correlation 0.63
• Phagocytic Membrane Signaling · correlation 0.57
• Inflammatory Resolution · correlation 0.53
• Inflammasome IL-1 Response · correlation 0.51
• CC Chemokine Secretion · correlation 0.40

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.