KLF2 Survival Response
Gene co-expression module in Neutrophils
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include MYADM (myeloid-associated differentiation marker), KLF2 and KLF6 (Krüppel-like factors involved in survival and shear stress response), FOSB (AP-1 immediate-early TF), YPEL5 (small GTPase-related), BEST1 (bestrophin-1 chloride channel), JMJD1C (histone demethylase), IDS (iduronate 2-sulfatase, lysosomal), YWHAZ (14-3-3 zeta), RASSF5 (Ras association domain). KLF2 is a well-established flow/shear stress and survival factor in leukocytes. FOSB and KLF6 suggest immediate-early/stress activation. The module appears to represent a survival/quiescence or early activation state. The neighborhood context (neighbors M49 with IEGs, M46 with chemokines) supports an early activation/stress program. KLF2 in neutrophils is associated with retention in bone marrow and naive state.
Genes
BEST1, FOSB, IDS, JMJD1C, KLF2, KLF6, MYADM, RASSF5, YPEL5, YWHAZ
Most correlated modules
- Interferon Stimulated Genes · correlation 0.67
- Myeloid Inflammatory Activation · correlation 0.64
- Immediate Early Response · correlation 0.58
- NF-κB Activation · correlation 0.55
- Bacterial Phagocytosis Program · correlation 0.54
- Phagocytic Membrane Signaling · correlation 0.52
- Inflammatory Resolution · correlation 0.50
- Myeloid Identity · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.