Golgi-Endosomal Sorting
Gene co-expression module in Neutrophils
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 40 genes have a known function matching the annotation |
Why this annotation
AP3B1 hub (AP-3 adaptor for lysosome-related/granule cargo sorting) with Golgi glycosylation enzymes (GALNT7, MGAT4A), TMEM59, TRAPPC12 and RAB11B, suggesting a Golgi-to-endosome trafficking component. However, membership is moderate and the module also includes splicing and SUMO genes, so the label is tentative.
Genes
Most correlated modules
- RNA Processing · correlation 0.60
- Proteasome/signalosome maintenance · correlation 0.59
- Generic Housekeeping · correlation 0.53
- Generic Housekeeping · correlation 0.53
- Sparse Housekeeping · correlation 0.52
- Cytokine feedback regulation · correlation 0.47
- ER Protein Translocation · correlation 0.47
- Electron Transport Chain · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.