Cytokine feedback regulation
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 29 genes have a known function matching the annotation |
Why this annotation
This low-detection module of moderate coherence mixes cytokine signaling genes (SOCS1, PSME2, FCGR2B, ARID5A, PRDM1, NCOA7, VAMP5) with RNA processing and nuclear genes (HNRNPR, SSB, FYTTD1, PRPF40A, UTP11, ZNF330, EZH2). SOCS1 and PSME2 indicate cytokine/IFN-JAK-STAT signaling with negative feedback. Its proximity to the ISG modules supports a late or regulatory phase of IFN-gamma stimulation.
Genes
Most correlated modules
- IFN-gamma response · correlation 0.84
- IFN-gamma response · correlation 0.82
- Cytosolic nucleic-acid sensing · correlation 0.71
- Interferon-stimulated genes · correlation 0.64
- Type I Interferon · correlation 0.64
- GM-CSF Cytokine Priming · correlation 0.63
- Ubiquitin-proteasome system · correlation 0.61
- Low-level housekeeping · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.