Mature Neutrophil Activation
Gene co-expression module in Neutrophils
| Category | Innate immunity |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes: PRELID1 (mitochondrial lipid transfer), MCEMP1 (mast cell/myeloid expressed membrane protein 1, marker of mature neutrophils/monocytes), UPP1 (uridine phosphorylase, pyrimidine metabolism), CD14 (monocyte/macrophage LPS co-receptor, but also on neutrophils), SLC2A3 (GLUT3, glucose transporter), C4orf3, TIMP1 (MMP inhibitor, inflammatory), ALOX5AP (5-lipoxygenase activating protein, leukotriene synthesis), TYMP (thymidine phosphorylase), AIF1 (Iba1, myeloid marker). CD14, MCEMP1, and AIF1 are myeloid maturation/activation markers. ALOX5AP links to leukotriene biosynthesis. TIMP1 is an inflammatory mediator. SLC2A3 reflects metabolic adaptation. This module represents a mature/activated neutrophil metabolic and inflammatory state, with elements of monocyte-like activation. The combination of myeloid markers, glucose metabolism, and inflammatory mediators suggests mature neutrophil activation.
Genes
AIF1, ALOX5AP, C4orf3, CD14, MCEMP1, PRELID1, SLC2A3, TIMP1, TYMP, UPP1
Most correlated modules
- Phagocytic Membrane Signaling · correlation 0.72
- Myeloid Identity · correlation 0.65
- Neutrophil Survival Program · correlation 0.65
- Inflammasome IL-1 Response · correlation 0.46
- Immediate Early Response · correlation 0.44
- Neutrophil Adhesion Signaling · correlation 0.43
- S100 Alarmin Response · correlation 0.41
- Inflammatory Resolution · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.