ER Protein Translocation
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 46 genes have a known function matching the annotation |
Why this annotation
Hub genes are ER translocon and secretory machinery components (TRAM1, SEC61B, SPCS3, TMEM258, PDIA6, TMED9). Alongside these are OxPhos subunits (NDUFS5, COX4I1, UQCRQ), TOMM7 and translation factors (EIF1AX, EEF1B2, EIF3G). Expression is low and uniform, consistent with a housekeeping protein-synthesis/ER-translocation program. This is likely a less-mature neutrophil or higher-RNA-content cell state rather than a specific activation program.
Genes
Most correlated modules
- Proteasome/Biosynthetic State · correlation 0.89
- Generic Housekeeping · correlation 0.78
- mRNA splicing/proteostasis · correlation 0.67
- Generic housekeeping background · correlation 0.62
- RNA Processing Housekeeping · correlation 0.51
- RNA Processing · correlation 0.48
- Golgi-Endosomal Sorting · correlation 0.47
- mRNA Splicing · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.