Pro-resolving tissue state
Gene co-expression module in Neutrophils
| Category | Tissue adaptation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
This is a low-detection module. HPGD degrades PGE2, ANXA1 is a pro-resolving mediator, DHRS9 is involved in retinoid metabolism, and HGF is a tissue-repair factor stored in neutrophil granules. HP (haptoglobin) is a specific-granule protein. GADD45A and MSRA indicate stress and repair. Together these suggest a tissue-adapted, pro-resolving or repair state in colonic neutrophils, distinct from the blood-like modules M62 and M36. It may also reflect mucosal retinoid and prostaglandin signals.
Genes
Most correlated modules
- Glucocorticoid alarmin response · correlation 0.85
- Mature antimicrobial recognition · correlation 0.81
- Mature circulating neutrophil · correlation 0.72
- Mature neutrophil identity · correlation 0.66
- Generic housekeeping · correlation 0.58
- TLR4/LPS activation · correlation 0.56
- Gi-coupled chemotactic cytoskeleton · correlation 0.54
- Electron Transport Chain · correlation 0.44
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.