Actin Cytoskeleton Dynamics
Gene co-expression module in Neutrophils
| Category | Cytoskeletal |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
CFL1 (cofilin-1) and PFN1 (profilin-1) are actin dynamics regulators essential for neutrophil motility. ACTB and ACTG1 are beta- and gamma-actin, core cytoskeletal components. MYL6 is myosin light chain 6. CORO1A (coronin-1A) and ARPC5 are Arp2/3 complex-associated proteins driving actin polymerization. S100A8 and S100A9 form the calprotectin complex, regulating cytoskeletal rearrangements and inflammation. ITGB2 (CD18) mediates neutrophil adhesion. TLN1 (talin-1) links integrins to actin. S100P is a calcium-signaling protein. TALDO1 is a pentose phosphate enzyme. This is a strongly coherent module dominated by actin cytoskeletal machinery for neutrophil migration and shape change.
Genes
ACTB, ACTG1, ARPC5, CFL1, CORO1A, ITGB2, MYL6, PFN1, RGL4, S100A8, S100A9, S100P, TALDO1, TLN1, TSPO
Most correlated modules
- Pentose Phosphate Pathway · correlation 0.77
- S100 Alarmin Response · correlation 0.75
- Specific Granule Release · correlation 0.72
- Neutrophil Motility Cytoskeleton · correlation 0.67
- Neutrophil Differentiation · correlation 0.65
- NET Priming State · correlation 0.60
- Secondary Granule Antibacterial · correlation 0.57
- Immature Neutrophil Granule · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.