Endosomal Vesicle Trafficking
Gene co-expression module in Neutrophils
| Category | Vesicular traficking |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes SMAP2 (ArfGAP, endosomal trafficking), SORL1 (sorting receptor, vesicular transport), FLOT2 (lipid raft/endocytosis scaffold), and MYO1F (actin motor for vesicular transport in neutrophils) converge strongly on intracellular vesicular trafficking and endosomal sorting. RGS18 regulates G-protein signaling downstream of trafficking receptors; IQGAP1 and RIPOR2 support cytoskeletal coupling to vesicle movement. The module is strongly coherent with uniform expression across neutrophil subsets, consistent with a constitutive endosomal trafficking program.
Genes
FKBP5, FLOT2, IQGAP1, MYO1F, RGS18, RIPOR2, SMAP2, SORL1
Most correlated modules
- PI3K Migration Signaling · correlation 0.95
- TLR5 Bacterial Sensing · correlation 0.94
- Stress Kinase Signaling · correlation 0.93
- Ubiquitin-Proteasome Turnover · correlation 0.93
- Granulopoiesis Transcriptional · correlation 0.93
- Endosomal Vesicle Trafficking · correlation 0.92
- ER Stress Response · correlation 0.92
- Mature Neutrophil Identity · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.