Immature Neutrophil Granule
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes are highly specific and coherent neutrophil markers: CD24 (neutrophil surface marker, also expressed in immature granulocytes), CEACAM8 (CD66b, canonical neutrophil granule membrane protein), RETN (resistin, neutrophil/monocyte cytokine), OLFM4 (olfactomedin 4, specific marker of immature/developing neutrophils and granules), CPNE3 (copine III, calcium-dependent membrane binding), SVIP (small VCP-interacting protein, ER-related), BPI (bactericidal/permeability-increasing protein, primary granule antimicrobial), CCDC85B, RGCC (regulator of cell cycle, expressed in neutrophils). This module strongly marks immature/developing neutrophils (OLFM4, CEACAM8, CD24, BPI are all enriched in specific granule or immature neutrophil populations). OLFM4 specifically marks a neutrophil progenitor/immature subset. BPI is a primary granule antibacterial protein. This module represents an immature neutrophil granule/maturation signature.
Genes
BPI, CCDC85B, CD24, CEACAM8, CPNE3, OLFM4, RETN, RGCC, SVIP
Most correlated modules
- mRNA Splicing Processing · correlation 0.85
- Secondary Granule Antibacterial · correlation 0.83
- Endocytic Vesicular Trafficking · correlation 0.80
- Proteostasis RNA Metabolism · correlation 0.75
- Mitotic Spindle · correlation 0.73
- Primary Granule Antimicrobial · correlation 0.71
- Myeloid Lipid Remodeling · correlation 0.68
- Apoptotic Neutrophil Program · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.