S-G2-M Cell Cycle
Gene co-expression module in Neutrophils
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes: ATAD2 (ATPase/chromatin remodeling, highly expressed in proliferating cells), EZH2 (histone H3K27 methyltransferase, Polycomb complex, cell proliferation marker), MIS18BP1 (CENP-A loading factor, kinetochore assembly, S/G2 phase), TOPBP1 (DNA replication initiation and checkpoint, S phase), VRK1 (vaccinia-related kinase 1, G1/S transition, chromatin condensation), SMC4 (condensin complex, mitotic chromosome condensation), CNTRL (centriolin, cytokinesis/centrosome), RRM2 (ribonucleotide reductase, S-phase specific, DNA synthesis), LNPEP (aminopeptidase), CENPP (centromere protein P, kinetochore). This is an exceptionally coherent cell cycle module — specifically S/G2/M phase. EZH2, ATAD2, RRM2 (S-phase), MIS18BP1, TOPBP1 (replication), VRK1 (G1/S), SMC4, CNTRL, CENPP (mitosis) are all canonical proliferation/cell cycle markers. In the context of neutrophils (whole body), this likely marks proliferating neutrophil precursors.
Genes
ATAD2, CENPP, CNTRL, EZH2, LNPEP, MIS18BP1, RRM2, SMC4, TOPBP1, VRK1
Most correlated modules
- Myeloid Maturation · correlation 0.91
- Proteostasis RNA Metabolism · correlation 0.91
- Mitotic Spindle · correlation 0.84
- Myeloid Lipid Remodeling · correlation 0.84
- mRNA Splicing Processing · correlation 0.80
- General Homeostatic Regulation · correlation 0.77
- Endocytic Vesicular Trafficking · correlation 0.76
- Primary Granule Antimicrobial · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.